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Colossus (Invest Like the Best / Business Breakdowns)Podcast16 Jul 2025Source: joincolossus.comHost: Colossus

Agilent: Back To The Lab - [Business Breakdowns, EP.223]

In plain words

This piece is about Agilent, a lab instrument company that makes most of its money from consumables and services, not equipment sales (only 1/3 of revenue). The guest sees it as an undervalued 'boring' business with a 34% service margin and a 2/3 share in gas chromatography, backed by 4,000 technicians. Key holdings: Agilent (service attach rate rising from 30% to 50%), Waters (higher attach rate at 50%), and Thermo Fisher (huge product range, but chromatography is just one part).

AI SummaryAI-generated · may contain errors · verify against the original

Agilent is a laboratory instruments and equipment company with a market capitalization of approximately $30 billion, primarily serving the life sciences, diagnostics, and applied chemical markets. The company originated from Hewlett-Packard and was spun off 25 years ago, giving it deep industry root

~13 min full read · 7 sections
Deep Analysis

This Issue Overview

Mark de Vos (fund manager at Troy Asset Management) is this episode's guest, analyzing Agilent—a life science tools company with a market cap of roughly $30 billion, tracing its roots to HP and specializing in laboratory instruments and consumables. The most significant judgment of the entire episode: Agilent does not make money from one-time equipment sales, but rather operates on a "razor and blade" model—instrument sales account for only 1/3 of revenue, while consumables and services account for 2/3, and the service business has a profit margin of 34%. However, the market underestimates the compounding growth potential of this "boring business."


Theme 1: Agilent's "Razor and Blades" Model – Revenue Structure of Instrument Sales and Consumables & Services

Mark de Vos argues that Agilent's core business logic is not selling equipment, but rather locking in customers through equipment and then continuously selling consumables and services, forming highly sticky revenue.

  • Revenue breakdown: Approximately 1/3 from instrument sales, 2/3 from consumables, services, and software. A typical chromatograph sells for about $100,000, with a useful life of 6–10 years. During that period, customers spend an average of another $100,000 on consumables and services. The core consumable is the "chromatography column" (column), which needs to be replaced after roughly 2,000 samples – as often as once a month. Services include repair, calibration, qualification, etc.
  • "Attach rate" metric: Agilent discloses a "service contract attach rate" – the proportion of installed instruments under service contracts – which has risen from the high 20% five years ago to the current low 30%, and is expected to increase by roughly 1 percentage point per year. Compared with peer Waters (approximately 50%), Agilent still has significant room for improvement.
  • Source of customer stickiness: In pharmaceutical customers' production quality testing processes, the methods are often written into FDA drug approval documents, even specifying the brand of instruments and consumables. Once approved, switching suppliers is costly and risky. Mark de Vos points out: "This provides strong protection for the recurring revenue from consumables and services."
Indicator Value
Instrument sales share Approximately 1/3
Consumables & services share Approximately 2/3
Typical chromatograph selling price Approximately $100,000
Useful life 6–10 years
Total consumables & services spend over lifetime Approximately $100,000
Column replacement frequency Every 2,000 samples or monthly
Current service contract attach rate Low 30%
Peer Waters attach rate Approximately 50%
Expected annual attach rate increase Approximately 1 percentage point

Theme 2: Competitive Landscape — Absolute Advantage in Gas Chromatography and the Service Moat

Mark de Vos argues that Agilent holds a dominant share in gas chromatography, and its service network is a more durable moat than technological innovation.

  • Market Position: Agilent holds approximately two-thirds of the global market share in gas chromatography instruments, far ahead of any competitor. Gas chromatography is primarily used in applied markets, such as battery testing, environmental pollutant detection, and petrochemical refining output analysis. In liquid chromatography, Agilent and Waters each have about one-third market share, with Thermo Fisher Scientific also holding a certain share. In spectroscopy, Agilent accounts for 40-50%.
  • Service Network Barrier: Agilent directly employs 4,000 service technicians, with 75% holding a bachelor's degree in chemistry or biochemistry, and 25% holding a master's or doctorate degree. It performs 2,500 on-site service visits per day. Mark de Vos emphasizes: "It is difficult to compete with this scale." The profit model of the service business is "density economics" — increasing business volume by 5% in the same city typically does not require additional headcount, only filling the schedules of existing technicians.
  • Market Stability Rather Than Innovation-Driven: The guest points out that market share has been highly stable over the past few decades, with a new product launch causing at most a 1-2 percentage point change. He cites a chart from Waters: "Sales data for a certain type of chromatography column has been essentially a straight line for decades." The reason remains the lock-in effect from regulatory approvals.
  • Competitive Comparison: Waters (approximately $3 billion in revenue) is more focused on liquid chromatography in the pharmaceutical market; Thermo Fisher ($43 billion in revenue) has an extremely broad product line, including laboratory refrigerators, test tubes, centrifuges, etc., with chromatography being just one of its many categories.
Competitive Dimension Agilent Waters Thermo Fisher
Total Revenue ~$6.5B ~$3B ~$43B
Gas Chromatography Share ~2/3 Very low Present but not dominant
Liquid Chromatography Share ~1/3 ~1/3 Has share
Spectroscopy Share 40-50% Relatively low Has share
Service Technician Scale 4,000 Smaller Very large but fragmented
Customer Concentration Diversified (pharma, food, environmental, semiconductor) ~60% pharma Extremely broad

Theme 3: NASD Business and PFAS Testing – Emerging Growth Opportunities and Risks

Mark de Vos argues that Agilent's self-developed 'Nucleic Acid Solutions Division' (NASD) and the emerging PFAS (forever chemicals) testing market are potential growth catalysts beyond the traditional business framework, but attention must be paid to their commercialization uncertainties.

  • NASD Business: A business incubated internally at Agilent, producing oligonucleotides (oligos) — short synthetic DNA or RNA strands used for treating genetic diseases and RNA vaccine/drug production. The business started in 2006, initially combining internal RNA synthesis capabilities with the acquisition of SignPro (a small company). In 2018, Agilent decided to invest $185 million to expand capacity; in 2023, it added another $725 million to build a new facility in Frederick, Colorado. Currently, its revenue is approximately $300 million, and together with the acquired BioVectra (acquired for approximately $1 billion), the total is approximately $470 million, accounting for about 7% of total revenue.
  • Business Model Difference: Unlike 'selling shovels,' NASD directly produces 'molecules' and collaborates with pharmaceutical companies in early-stage development, with scale exploding after commercialization. The guest noted: 'No other company has the same production capacity as Agilent, especially at production-grade volumes.'
  • PFAS (forever chemicals) Testing: This is a new market emerging from recent regulatory developments, with an annual market size of approximately $400 million growing at 20% per year. Agilent is a leader in applied market testing and thus a 'clear leader' in this field. Mark de Vos believes this is 'a market that suddenly appeared' and a source of potential excess returns.
  • Risk Warning: The guest acknowledges short-term risks — the pharmaceutical industry experienced a wave of instrument purchases post-COVID (2020-2021), followed by a digestion period (2022-2024), and has only recently returned to normal purchasing levels. China accounts for approximately 18% of group sales, subject to short-term volatility due to government subsidies and localization policies. However, NIH-related funding accounts for only about 1% of its sales, so the risk is manageable.
Emerging Business Current Revenue Scale Growth Trend Key Risks
NASD (oligos) Approximately $470 million (about 7% of total revenue) High growth, but depends on RNA drug commercialization Low single-client dependency risk, but industry financing environment volatile
PFAS Testing Market of approximately $400 million 20% annual growth Regulatory pace uncertain, but Agilent has already taken the lead

Theme 4: Valuation and Investment Logic – High Single-Digit Growth at a Reasonable Valuation and the "Boring Business" Premium

Mark de Vos believes that Agilent's current valuation – a P/E of roughly 22x and a free cash flow yield above 4% – is reasonable for a business with high single-digit growth and high cash conversion, but the market still underestimates the compounding power of its "boring business."

  • Financial Performance: From 2015 (post-Keysight spin-off) to 2024, Agilent's organic revenue grew at a CAGR of approximately 5%, while earnings per share grew at a CAGR of roughly 13%. Free cash flow stands at about $1.4 billion, with a cash conversion rate of roughly 90% (i.e., free cash flow / adjusted net income). The services business boasts a margin as high as 34%, significantly above instrument sales (around 20% in life sciences and about 24% in applied markets).
  • Price Logic: The guest notes that they typically value using free cash flow yield or P/E. Agilent's recent free cash flow yield exceeds 4%, close to its 10-year high, corresponding to a P/E of roughly 22x, which is "reasonable" for a business expected to deliver high single-digit earnings growth. He does not overcomplicate it: "If you like the long-term growth and the valuation is reasonable, invest."
  • Lessons from the "Boring Business": Mark de Vos highlights two investment lessons: First, do not underestimate "boring" businesses – the laboratory instrument servicing business has a 33% margin and stable growth. Second, picks-and-shovels providers often outperform end users – life science tools companies have consistently outperformed pharmaceutical companies over the long term.
  • Role of M&A: M&A plays a supporting rather than core role, mainly used to fill technology gaps (e.g., the recent acquisition of a laboratory software company) or complement adjacent products (e.g., BioVectra). The guest believes the likelihood of Agilent being acquired is low – if Thermo Fisher attempted an acquisition, the competitive review risk would be extremely high.
Valuation Metric Current Level Historical Range
Free Cash Flow ~$1.4 billion Annual conversion rate ~90% of adjusted net income
Free Cash Flow Yield Over 4% Near 10-year high
P/E (Price-to-Earnings) ~22x Comparable to the 10-year historical median
Organic Revenue Growth (CAGR) ~5% (2015-2024) -
EPS Growth (CAGR) ~13% (2015-2024) Driven by margin expansion

Mentioned Instruments

Instrument Guest Attitude Key Data
Agilent Bullish Market cap ~$30B; revenue ~$6.5B; free cash flow ~$1.4B; service margin 34%; gas chromatography market share ~2/3
Waters Neutral (competitive comparison) Revenue ~$3B; liquid chromatography share ~1/3; service contract stickiness ~50% (higher than Agilent)
Thermo Fisher Scientific Neutral (competitive comparison) Revenue ~$43B; extremely broad product line, chromatography is only one segment; service network fragmented
BioVectra Bullish (acquisition) ~$1B acquisition; complements NASD business, combined revenue of ~$470 million post-acquisition
Keysight Technologies Background mention Spun off from Agilent in 2014, currently listed independently; Agilent divested ~40% of its sales revenue at the time
Broadcom (via Avago) Background mention Agilent's former semiconductor components business was acquired by KKR/Silver Lake to become Avago, later merged into Broadcom

Judgments Worth Remembering

1. Mark de Vos: "The Underestimated 'Boring' Business" — Agilent's services business has a 33% margin, grows high single digits, and its "stickiness" still has a long way to go from the low 30% to 50%, but the market overlooks its quality due to the "repairing lab instruments" label.

2. Mark de Vos: "Tool Suppliers Outperform End Users" — Life science tool companies have long outperformed pharmaceutical companies. Agilent is a classic "selling shovels" example and benefits from customer stickiness driven by regulatory lock-in.

3. Mark de Vos: "Service Is the True Moat, Not Technology" — 4,000 technicians, 75% holding chemistry/biochemistry degrees, and 2,500 on-site service visits per day form a barrier more difficult to replicate than technology patents.

4. Mark de Vos: "The Cost for Customers to Switch Suppliers Is Nearly Infinite" — Once FDA approval documents specify Agilent's instruments and consumables, switching means re-approval, enormous costs, and uncontrollable risks. This is the fundamental source of "stickiness."

5. Mark de Vos: "Gas Chromatography Is Agilent's 'Crown Jewel'" — 2/3 global market share, covering non-cyclical application markets such as battery testing, environmental testing, petrochemical refining, and with a customer base that largely does not overlap with liquid chromatography, forming a natural hedge.

6. Mark de Vos: "The NASD Business Is a 'Rebirth of an Old Business'" — Starting from a small, inconspicuous merger in 2006, after 20 years of R&D, it has become a core supplier for RNA drug production, with unmatched capacity. Falsification Condition: If the commercialization progress of RNA drugs falls short of expectations, or if alternative technologies emerge, the investment may not be recovered.

7. Mark de Vos: "PFAS Testing Is an 'Unexpected Catalyst'" — A $400 million market that "suddenly emerged" from regulation, growing 20% annually, with Agilent as the clear leader. This provides investors with a "free option."

8. Mark de Vos: "22x PE Is Reasonable, But Don't Expect Valuation Expansion" — For a business with high single-digit growth and 90% cash conversion, the current valuation already reflects its quality. Excess returns will come from earnings growth, not multiple expansion.